Scientists have developed a new vaccine that — in conjunction with existing therapies — can not only treat aggressive melanoma, but also prevent its recurrence.
Researchers from the Scripps Research Institute in San Diego, CA, recently worked with experts from other institutions to develop a vaccine that would be effective against melanoma (a type of skin cancer) when administered in conjunction with other therapies.
According to Prof. Dale Boger, who co-led the research with Nobel laureate Bruce Beutler, “This co-therapy produced a complete response — a curative response — in the treatment of melanoma.”
These promising results are reported in a study paper now published in the journal PNAS.
Experimental approach fully successful
The researchers tested three different therapy options in a mouse model of aggressive melanoma. All of the mice received a type of cancer immunotherapy known as anti-PD-L1, but in addition to this, they also received different vaccine variants.
Prof. Boger and team split the mice into three groups: one group had the cancer vaccine, another group had the vaccine plus a molecule called Diprovocim, and the third group had the cancer vaccine and another adjuvant: a chemical known as alum.